Lysosomal storage diseases are a rare collection of conditions that are inherited. Many of them are more prevalent in certain breeds and are seen in the first few months of life. Clinical signs vary depending on the type of disease, but commonly include failure to thrive, incoordination, vision loss, and seizure. Prognosis is usually poor for long-term survival.

Hemophilia A and B are clotting disorders involving a deficiency of a specific clotting factor (A: Factor VIII, B: Factor IX) needed for appropriate homeostasis. They are caused by a sex-linked recessive genetic mutation. Affected dogs will show inappropriate hemorrhage including bruising, lameness induced by bleeding into joints and body cavity hemorrhage. It can be diagnosed with a slow APTT and demonstrating low levels of the factor involved. Hemophilia A is more common than B and is generally, more severe. Because it is sex-linked recessive, males are more likely to be affected than females but females still act as carriers, so genetic screening is important prior to breeding to prevent this disease.

False pregnancy refers to a display of maternal behaviors, combined with the physical signs of pregnancy following estrus, in unspayed female dogs that are not actually pregnant. Signs include physical and behavioral changes, outlined in this article. Mild cases typically are not treated, but treatment may be needed for more serious cases. If your dog is not used for breeding, spaying is recommended.

Estrus (heat) begins when a female dog reaches sexual maturity and occurs about twice per year, although it varies from dog to dog. From the beginning of a female’s estrus period, she will be attractive to male dogs, though she will usually not be receptive or allow mating until seven to ten days into her cycle. The time of mating is extremely critical and it is highly recommended to have your female tested to determine the optimal days for breeding.