The pro-opiomelanocortin (POMC) gene, if mutated, can contribute to increased body fat and body weight and increased food motivation in affected dogs. At this time, this gene mutation has only been found in the Labrador Retriever and Flat-coated Retriever and affects the majority of those working as service dogs.This handout explains how the POMC gene mutation was discovered, how it impacts affected dogs, and how you can support your dog if affected.