Like humans, benign and malignant tumors occur in dogs’ mouths. Peripheral odontogenic fibromas (POF) are the most common benign tumors while oral melanomas, squamous cell carcinomas, and fibrosarcomas are the most prevalent malignant tumors in dogs. Diagnosis may be performed via fine needle aspiration or biopsy. Spread to mandibular lymph nodes does occur. Fine needle aspiration of the lymph nodes is recommended when malignant tumors are suspected. Tumor staging including laboratory testing as well as CT imaging helps to plan therapy.

Oral melanomas are the most common malignant oral tumor in dogs. Melanomas usually present as a mass in the mouth and may be melanotic (pigmented) or amelanotic (non-pigmented). These tumors are both locally invasive and have a high tendency to metastasize to other organs. Full staging including CT scanning is recommended to determine the extent of the disease.

Fibrosarcomas are the third most common oral tumor in dogs and arise from the fibrous and connective tissues of the oral cavity. These tumors are very invasive locally and are often difficult to manage, Diagnosis is based on biopsy. Treatment involving surgery and radiation provide the longest survival times.

Oral squamous cell carcinomas (SCC) are the most common oral tumor in cats, and second most common in dogs. These tumors are locally aggressive, with a possibility to metastasize. Regardless of the location of SCC, surgery is the typically the standard treatment. Radiation therapy may be recommended following surgery or as a primary treatment for palliative care. Staging is recommended for all cases. If metastasis is present chemotherapy is often pursued.

Odontogenic fibromas, sometimes previously referred to as an epulis, are benign tumors of the mouth often at the front of the upper jaw. These may be locally invasive and may cause some oral pain. Surgery is the recommended course of action to treat this condition.