Orphaned puppies will need extra care for survival to compensate for the loss of their mother. Puppies must be kept warm, very clean, and fed frequently using an appropriate amount and type of formula by bottle or less often tube feeding. To ensure nutrition is adequate, daily weight checks should be performed for the first 4 weeks, then weekly thereafter. Puppies must be stimulated to urinate and defecate. Environment, feeding instruments and the puppy must be kept meticulously clean as they are more susceptible to infection than puppies cared for by their mother.