AIHA or IMHA is a life-threatening condition that may occur as a primary condition or secondary to another disease. Most dogs with AIHA have severe anemia and their gums will be very pale. They will be anorexic, listless, easily tired, and will have increased heart and respiration rates. Diagnosis involves a complete blood count (CBC), biochemical profiles, urinalysis, and X-rays or ultrasound of the abdomen and chest. Treatment may involve blood transfusions and other medications over a prolonged time. The prognosis may be better if an underlying cause can be identified.

An aortic thromboembolism (ATE) results when a blood clot is dislodged and travels through the aorta, becoming lodged in a distant location. This clot causes severely reduced blood flow to the tissues receiving blood from that section of the aorta, leading to decreased oxygen in the tissues. Aortic thromboembolism is a rare occurrence in dogs and can be associated with endocarditis, cancer, sepsis, hyperadrenocorticism, and increased protein loss through diseased kidneys. This article outlines clinical signs, treatment, monitoring, and prognosis for dogs with this condition.