Acetaminophen with codeine (brand name Tylenol with Codeine, Tylenol #3) is a combination drug that is used for pain management in humans. Acetaminophen is a pain reliever and fever reducer. It is not often used in animals and, when done so, must only be used in dogs. It is often combined with the drug codeine which is a narcotic pain reliever. Acetaminophen/codeine comes in a variety of formulations.