Afoxolaner/moxidectin/pyrantel (brand name Nexgard Plus) is a prescription combination parasiticide used in dogs. It is labeled for use as a preventative for heartworm caused by Dirofilaria immitis in dogs; to treat and control tick infestations in dogs caused by black-legged ticks, brown dog ticks, American dog ticks, and lone star ticks; to treat and control adult roundworm and hookworm infections in dogs; to kill adult fleas on dogs and to treat and prevent flea infestations.